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Development of successful antibody drugs from human antibody mice

The VelocImmune mouse is a second generation transgenic chimeric mouse and has yielded four approved drugs (Table 5) . Dupilumab (Dupixent, Sanofi and Regeneron, human IgG4) binds to IL-4 receptor and inhibits the IL-4 and IL-13 pathway, as an eczema treatment. Sarilumab (Kevzara, Sanofi and Regeneron, human IgG1) inhibits IL-6 signaling by binding to the IL-6 receptor (IL-6R), which otherwise would upregulate the Year of the first US FDA approval release of rheumatoid arthritis-related factors from hepatocytes. The two drugs were both approved in 2017.